After losing her parents, novice pharmacist Rune is left with enormous debts on Tiara Island. Pressured by the ruthless lender Charvan, who saves her from an orc assault only to demand repayment through her body or business earnings, Rune takes over the family pharmacy. She ventures into perilous areas to collect herbs and materials, brewing potions to sell while facing constant sexual threats and exploitation. From fending off monsters like cyclopes and slimes to satisfying powerful figures such as a futanari noblewoman Mei and the island lord Georg, Rune's efforts to earn money and create advanced medicines lead to increasingly depraved situations—including anal violations, regression drugs, and tentacle-like slime assaults. Despite her determination to become a full-fledged pharmacist and clear the debt, each quest spirals into erotic submission. The series explores themes of desperation, corruption through pleasure, and fantasy erotica in a short but intense 4-volume ONA format produced by SELFISH, highlighting Rune's transformation from shy apprentice to reluctant participant in carnal adventures.